Informatics Publishing Limited

P. K. Srivastava , A. A. Siddiqui , A. K. Goel

Abstract

Half sib seedlings belonging to 24 Terminalia arjunatrees located in M. P., Orissa and Bihar were quantitatively measured for leaf and height characters to assess variability and superiority in the seedlings. High heritability, high genetic advance and high genetic coefficient of variation were found for seedling height which indicates additive gene action for this character where as low GCV, low genetic advance and high heritability were noted for remaining leaf characters suggesting thereby intra and inter-allelic interaction for leaf characters. The O1, 02 and N4 have been found to be best performers in the descending order followed by D, Ds1, Nl, Ds4, N3, B1 and B2.

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S. Siddiqui ¹, S. Sharma ², B. Sharma ³, A. A. Siddiqui ²

Affiliations
1 Subramanium College of Science and Technology, New Delhi–110082, IN
2 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, IN
3 Department of Pharmacy, Bundelkhand University, Jhansi (UP), IN

Abstract

Serendipity, in various shades of semantic legitimacy, is abundantly evident in history of drug discovery. In the present era, although new concept of rational drug design has been introduced even then, lots of drugs have arisen, and continue to arise, from chance observation and correct scientific methods. Chance does not produce drugs; but where chances have played a pivotal role in drug discovery, the event may be considered as serendipitous.

Keywords

Discovery, Serendipity, Penicillin.

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S. Siddiqui ¹, S. Kumar ², A. A. Siddiqui ², S. Kataria ², S. Paliwal ³

Affiliations
1 Subramanium College of Science and Technolgy, Holambi Khurd, New Delhi -110 082, IN
2 Department of Pharmaceutical Chemistry, Jamia Hamdard, New Delhi -110 062, IN
3 Department of Pharmacy, Banasthali University, Banasthali Vidyapeeth, Rajasthan-304 022, IN

Abstract

Treatment of cancer is a challenge to physicians, and it requires multiple treatments. But the role of paclitaxel cannot be neglected in cancer treatment. It is the most promising anti tumour agent. As the drug has poor water solubility, number of alternative controlled release formulations has been developed having variety of dose regimens to overrule the limitations of cremophor based formulation. More advanced Drug delivery systems includes Nanoparticles, Microemulsion, Liposomes, Oncogel, Microspheres, Cyclodextrin complex, etc. Also the drug has flexible structural aspects hence lots of modifications are possible in the structure.

Keywords

Paclitaxel, Cremophor, Nanoparticles, Formulations.

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